Journal: bioRxiv
Article Title: NRF2 co-opts the SWI/SNF complex to drive liver cell plasticity
doi: 10.64898/2026.02.09.704724
Figure Lengend Snippet: (A) Volcano plot of DEGs identified by bulk RNA-Seq analysis of livers from adult TO:NRF2 T80K zebrafish treated with DOX versus DMSO for 4 weeks, n=3. Significant DEGs are highlighted in pink. Select canonical NRF2 target genes are highlighted in blue. (B) UMAP visualization of gstp1 expression in livers from adult TO:NRF2 T80K zebrafish treated with DMSO or DOX for 3 weeks. (C) Masson’s trichome stained histological sections from livers isolated from adult TO:NRF2 T80K zebrafish after 4 weeks treatment with DMSO or DOX. Scale bars represent 50 µm. (D) TUNEL- and DAPI-stained histological sections from livers isolated from adult TO:NRF2 T80K zebrafish after 4 weeks treatment with DMSO or DOX. DNase I treatment was employed as a positive control. Scale bars represent 50 µm.
Article Snippet: The section used as a positive control was treated with DNase I (Zymo Research, E1010) at room temperature for 10 mins.
Techniques: RNA Sequencing, Expressing, Staining, Isolation, TUNEL Assay, Positive Control